FPIES is a clinical diagnosis, which means there are currently no tests to make or confirm the diagnosis.  There are no standard treatment protocols, yet.  Research and advancements are being made by doctors all over the world to advance the understanding of FPIES and to bring about better management strategies and outcomes for those affected by this condition.

med lit collage

General FPIES:

Syndrome D’Entérocolite Induit Par Les Protéines Alimentaires (SEIPA) et Manifestations Digestives De L’Allergie Alimentaire. 

J.-C. Caubet. Syndrome d’entérocolite induit par les protéines alimentaires (SEIPA) et manifestations digestives de l’allergie alimentaire Revue Française d’Allergologie, Volume 57, Issue 3, Pages 136-137.

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International Consensus Guidelines for the Diagnosis and Management of Food Protein-Induced Enterocolitis Syndrome.

Nowak-Węgrzyn, A. et al. I nternational Consensus Guidelines for the Diagnosis and Management of Food Protein-Induced Enterocolitis Syndrome. Journal of Allergy and Clinical Immunology ,  2017 Feb 3.

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Severely Altered-Consciousness Status and Profuse Vomiting in Infants: Food Protein-Induced Enterocolitis Syndrome (FPIES) a Challenging Diagnosis. 

Barasche, Judith; Stollar, Fabiola; Bergmann, Marcel M.; Caubet, Jean-Christoph. Severely Altered-Consciousness Status and Profuse Vomiting in Infants: Food Protein-Induced Enterocolitis Syndrome (FPIES) a Challenging Diagnosis. Pediatric Emergency Care. Illustrative Case: PDF Only. 

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Food protein-induced enterocolitis syndrome: Pitfalls in the diagnosis.

Guibas GV, Tsabouri S, Makris M, Priftis KN. Food protein-induced enterocolitis syndrome: Pitfalls in the diagnosis. Pediatr Allergy Immunol 2014: 00.

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FPIES: Reviewing the Management of Food Protein-Induced Enterocolitis Syndrome.  

Neha Khanna and Kirtika Patel, “FPIES: Reviewing the Management of Food Protein-Induced Enterocolitis Syndrome,” Case Reports in Pediatrics, vol. 2016, Article ID 1621827, 5 pages, 2016. 

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Ondansetron in acute food protein‐induced enterocolitis syndrome, a retrospective case‐control study. 

Miceli Sopo S, Bersani G, Monaco S, Cerchiara G, Lee E, Campbell D, Mehr S. Ondansetron in acute food protein-induced enterocolitis syndrome, a retrospective case–control study. Allergy 2016; DOI: 10.1111/all.13033.

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Clinical presentation and referral characteristics of food protein-induced enterocolitis syndrome in the United Kingdom

Siân Ludman, MBBCh; Mark Harmon, BSc, MBBS; Danielle Whiting, BSc (Hons), MBBS; George du Toit, FRCPCH. Clinical presentation and referral characteristics of food protein-induced enterocolitis syndrome in the United Kingdom.Annals of Allergy, Asthma & Immunology Volume 113, Issue 3, September 2014, Pages 290–294. 

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Resolution of acute food protein-induced enterocolitis syndrome in children

Lee, Eric; Campbell, Dianne E.; Barnes, Elizabeth H.; Mehr, Sam S. Resolution of acute food protein-induced enterocolitis syndrome in children. The Journal of Allergy and Clinical Immunology: In Practice. 2016. 

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Non-IgE-Mediated Food Allergy: FPIES

Anna Nowak-Węgrzyn;  George Konstantinou. Non-IgE-Mediated Food Allergy: FPIES.Current Pediatrics Reports June 2014, Volume 2, Issue 2, pp 135-143 Date: 19 Mar 2014.

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Factors Affecting the Attainment of Tolerance Status in a Cohort of Food Protein-Induced Enterocolitis Patients

Lee, Eric C.K. et al. Factors Affecting the Attainment of Tolerance Status in a Cohort of Food Protein-Induced Enterocolitis. PatientsJournal of Allergy and Clinical Immunology , Volume 137 , Issue 2 , AB240

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Non IgE-mediated Gastrointestinal Food Allergies in children Caubet J-C, Szajewska H, Shamir R, Nowak-Węgrzyn A. Non-IgE-mediated gastrointestinal food allergies in children. Pediatr Allergy Immunol 2017: 28: 6–17.

headercolorbarNon–IgE-mediated gastrointestinal food allergy. 

Nowak-Węgrzyn, Anna et al. Non–IgE-mediated gastrointestinal food allergy. Journal of Allergy and Clinical Immunology , Volume 135 , Issue 5 , 1114 – 1124 

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The Clinical Prehistory of Food-Protein Induced Enterocolitis Syndrome (FPIES) Pecora, Valentina et al.  The Clinical Prehistory of Food-Protein Induced Enterocolitis Syndrome (FPIES). Journal of Allergy and Clinical Immunology , Volume 137 , Issue 2 , AB240

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Severe Food Protein Induced Enterocolitis Syndrome (FPIES) in the Pediatric Intensive Care Unit (PICU): A Retrospective Chart Review.

Weinberger, Tamar et al. Journal of Allergy and Clinical Immunology , Volume 135 , Issue 2 , AB47headercolorbar

Clinical features and resolution of food protein–induced enterocolitis syndrome: 10-year experience. 

Jean Christoph Caubet, MD; Lara Simone Ford, MD, MPH; Laura Sickles, BA; Kirsi M. Järvinen, MD, PhD; Scott H. Sicherer, MD; Hugh A. Sampson, MD; Anna Nowak-Węgrzyn, MD;. Clinical features and resolution of food protein–induced enterocolitis syndrome: 10-year experience. Journal of Allergy and Clinical Immunology Volume 134, Issue 2, August 2014, Pages 382–389.e4

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Review article: the diagnosis and management of food allergy and food intolerances 

J. L. Turnbull, H. N. Adams, D. A. Gorard.  Review article: the diagnosis and management of food allergy and food intolerances.   Alimentary Pharmacology & Therapeutics Volume 41, Issue 1, pages 3–25, January 2015.

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Food Protein-Induced Enterocolitis Syndrome: Pitfalls in the Diagnosis.  Guibas GV, Tsabouri S, Makris M, Priftis KN. Food protein-induced enterocolitis syndrome: Pitfalls in the diagnosis. Pediatr Allergy Immunol 2014: 00.

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Drug-induced enterocolitis syndrome (DIES). 

Novembre E, Mori F, Barni S, Pucci N.Drug-induced enterocolitis syndrome (DIES). Pediatr Allergy Immunol. 2014 Jun;25(4):415-6.

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Unmet Needs in Food Protein-Induced Enterocolitis Syndrome.

Wang, Julie; Fiocchi, Alessandro. Unmet needs in food protein-induced enterocolitis syndrome.  Current Opinion in Allergy and Clinical Immunology. 2014 Jun;14(3):206-7.

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Knowledge of Food Protein-Induced Enterocolitis (FPIES) Among General Pediatricians. 

Nikhil Menon, Elizabeth Feuille, Faith Huang, Anna H. Nowak-Wegrzyn.  Knowledge of Food Protein-Induced Enterocolitis (FPIES) Among General Pediatricians.  Journal of Allergy and Clinical Immunology Vol. 131, Issue 2, Supplement, Page AB177.

headercolorbarFood Protein-Induced Proctitis/Colitis, Enteropathy, and Enterocolitis of Infancy   

This article defines the differential diagnosis for symptoms that present in infancy. Abstract available only. Available for purchase through qualifying UpToDate membership.    

Lake, A. Food Protein-Induced Proctitis/Colitis, Enteropathy, and Enterocolitis of Infancy. UpToDate,  February 2012, Retrieved from: http://www.uptodate.com/contents/food-protein-induced-proctitis-colitis-enteropathy-and-enterocolitis-of-infancy

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La FPIES (Food Protein-Induced Enterocolitis Syndrome)

L’Erario, D. Giglia, M. Londero, L. Badina, P. Moras, M.F. Pasquale, G. Longo. LA FPIES (FOOD PROTEIN-INDUCED ENTEROCOLITIS SYNDROME). Medico e Bambino 2012;31:298-306

Immunology:

Allergy:

A Very Unusual Case of Food Allergy, Between FPIES and IgE-Mediated Food Allergy.

Miceli Sopo, Monaco, Cerchiara, Bersani. A Very Unusual Case of Food Allergy, Between FPIES and IgE-Mediated Food Allergy. Eur Ann Allergy Clin Immunol. 2017 Jan;49(1):42-44.

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Non-IgE-Mediated Food Allergy: FPIES.  

Anna Nowak-Węgrzyn,   George Konstantinou. Non-IgE-Mediated Food Allergy: FPIES. Current Pediatrics Reports June 2014, Volume 2, Issue 2, pp 135-143 

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Is This Symptom Even a Food Allergy?: Clinical Types of Food Protein-induced Enterocolitis Syndrome 

Hwang JB. Is This Symptom Even a Food Allergy?: Clinical Types of Food Protein-induced Enterocolitis Syndrome. Pediatr Gastroenterol Hepatol Nutr. 2014 Jun;17(2):74-9.

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Friend or foe? Figuring out the difference between FPIES, IgE-mediated allergy and food intolerance.

Michelle Halbrich, Moshe Ben-Shoshan, Gregory Rex.  Friend or foe? Figuring out the difference between FPIES, IgE-mediated allergy and food intolerance.BMJ Case Reports 2014:published online 17 April 2014, doi:10.1136/bcr-2013-200254. 

 

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A Multicentre Retrospective Study of 66 Italian Children with Food Protein-Induced Enterocolitis Syndrome: Different Management for Different Phenotypes.   

An insight into FPIES from an Italian article, also shows a significant increase in FPIES over the last few years, and discusses management aspects within different phenotypes.  

Sopo SM, Giorgio V, Dello Iacono I, Novembre E, Mori F, Onesimo R.   A Multicentre Retrospective Study of 66 Italian Children with Food Protein-Induced Enterocolitis Syndrome: Different Management for Different Phenotypes. Clin Exp Allergy. 2012 Aug;42(8):1257-65.

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Protein Intolerance   

An annually updated, comprehensive protein intolerance overview including differentials for diagnosis 

Nocerino, A.; Guandalini, S. Protein Intolerance. Retrieved from:  http://emedicine.medscape.com/article/931548-overview.

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Non-IgE Food Allergy  

Written by a doctor researching protein intolerances in many populations, this article contains in depth discussion of the involvement of the GI tract in non-IgE mediated allergies. This article recognizes the necessity of early recognition and treatment for the management of both non-IgE allergies and FPIES specifically. 

Jyonouchi, H. Non-IgE Food Allergy. Inflammation & Allergy. Drug Target. 2008; 7(3): 1-7.

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Nonimmunoglobin E-Mediated Immune Reactions to Foods  

This article, published in 2006, recognizes the increase in Non-IgE food allergy. Includes a table for differential diagnosis within Non-IgE allergy

Spergel, J. Nonimmunoglobin E-Mediated Immune Reactions to Foods. Allergy, Asthma & Clinical Immunology, 2006; 2 (2): 78-85.

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Immunology:

Systemic Innate Immune Activation in Food Protein Induced Enterocolitis Syndrome (FPIES). 

Goswami, Ritobrata et al. Systemic Innate Immune Activation in Food Protein Induced Enterocolitis Syndrome (FPIES)Journal of Allergy and Clinical Immunology, 2017 Feb 9.

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Elevation of fecal eosinophil-derived neurotoxin in infants with food protein-induced enterocolitis syndrome

Wada, T., Toma, T., Muraoka, M., Matsuda, Y. and Yachie, A. (2014), Elevation of fecal eosinophil-derived neurotoxin in infants with food protein-induced enterocolitis syndrome. Pediatric Allergy and Immunology. doi: 10.1111/pai.12254.

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Infants with Food Protein-Induced Enterocolitis Syndrome (FPIES) Can Be Classified Into Two Distinct Subgroups Based On the Presence or Absence of Bloody Stool and Their Antigen-Specific Cytokine Production Profiles

Morita, Hideaki et al. Infants with Food Protein-Induced Enterocolitis Syndrome (FPIES) Can Be Classified Into Two Distinct Subgroups Based On the Presence or Absence of Bloody Stool and Their Antigen-Specific Cytokine Production Profiles.Journal of Allergy and Clinical Immunology , Volume 131 , Issue 2 , AB182. 

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Increased CRP level and fever in infants with FPIES in Japan.

Kimura, M., Ito, Y., Tokunaga, F., Meguro, T., Shimomura, M., Morishita, H., and Seto, S. (2016)Increased C-reactive protein and fever in Japanese infants with food protein-induced enterocolitis syndrome. Pediatrics International, doi: 10.1111/ped.12938.

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Immunopathophysiology of food protein–induced enterocolitis syndrome.  

Berin, M. Cecilia.  Immunopathophysiology of food protein–induced enterocolitis syndrome.  Journal of Allergy and Clinical Immunology. 2015 March 4. 

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Clinical Features and Resolution of Food Protein–Induced Enterocolitis Syndrome: 10-year Experience.  

Caubet, Jean Christoph et al. Clinical features and resolution of food protein–induced enterocolitis syndrome: 10-year experience.  Journal of Allergy and Clinical Immunology , Volume 134 , Issue 2 , 382 – 389.e4  

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Clinical Presentation and Referral Characteristics of Food Protein-Induced Enterocolitis Syndrome in the United Kingdom.

Ludman, Siân et al. Clinical presentation and referral characteristics of food protein-induced enterocolitis syndrome in the United Kingdom. Annals of Allergy, Asthma & Immunology , Volume 113 , Issue 3 , 290 – 294 

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Food Protein-Induced Enterocolitis Syndrome due to Oysters Ingestion

Stefano Miceli Sopo MD, Annamaria D’Antuono MD, Alessia Morganti MD and Annamaria Bianchi MD. Food Protein-Induced Enterocolitis Syndrome due to Oysters Ingestion.  IMAJ VOL 17March 2015 

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Differential Diagnosis of Food Protein-Induced Enterocolitis Syndrome 

Alessandro Fiocchi; Alessia Claps; Lamia Dahdah; Giulia Brindisi; Carlo Dionisi-Vici; Alberto Martelli.  Differential diagnosis of food protein-induced enterocolitis syndrome. Current Opinion in Allergy and Clinical Immunology. Current Opinion in Allergy and Clinical Immunology. June 2014, p 246-254.

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Food Protein-Induced Enterocolitis Syndrome, From Practice to Theory.   

Published in August 2013, a comprehensive look at management approaches based on current knowledge and discusses considerations for future research.   

Stefano Miceli Sopo, Monica Greco, Serena Monaco, Salvatore Tripodi, Mauro Calvani. Food Protein-Induced Enterocolitis Syndrome, From Practice to Theory.  Expert Rev Clin Immunology. 2013 Aug;9(8):707-15.

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Oral tolerance in patients with food protein induced enterocolitis syndrome (FPIES); Evidence of impaired induction of oral tolerance in FPIES patients with persistent reaction to multiple foods.

Harumi Jyonouchi, Lee Geng, Deanna Streck, Gokce Toruner. Oral tolerance in patients with food protein induced enterocolitis syndrome (FPIES); Evidence of impaired induction of oral tolerance in FPIES patients with persistent reaction to multiple foods. The Journal of Immunology, 2012, 188, 123.9 (Meeting Abstract Supplement).

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Non resolution of infantile Food Protein Induced Enterocolitis Syndrome (FPIES) (An abstract PDF). 

PJ Busse, HA Samspon, SH Sicherer.  Non resolution of infantile Food Protein Induced Enterocolitis Syndrome (FPIES)   J ALLERGY CLIN IMMUNOL VOLUME 105. NUMBER 1, PART 2

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Use of Food Challenge to Distinguish Food Protein-Induced Enterocolitis Syndrome from Hereditary Fructose Intolerance.  

M.A. Ruffner, D.N. Finegold, A.J. MacGinnitie.  Use of Food Challenge to Distinguish Food Protein-Induced Enterocolitis Syndrome from Hereditary Fructose Intolerance. Journal of Allergy and Clinical Immunology Vol. 127, Issue 2, Supplement, Page AB181.  Feb. 2011.

Guidelines:

Food Protein Induced Enterocolitis Syndrome (FPIES) on UpToDate, an online medical resource for providers. Abstract available only. Available for purchase through qualifying UpToDate membership.  Outlines current understanding of epidemiology, pathogenesis, clinical features, differential diagnosis, natural history and management. Includes tables for clinical features of acute vs. chronic FPIES, oral food challenge, differential diagnosis, symptoms of anaphylaxis, and pediatric systemic inflammatory response syndrome criteria.

Nowak-Węgrzyn,A.  Food Protein Induced Enterocolitis Syndrome (FPIES). UpToDate, January 2013.  Retrieved from: http://www.uptodate.com/contents/food-protein-induced-enterocolitis-syndrome-fpies

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Safety of Performing Oral Food Challenges to Food Protein-Induced Enterocolitis Syndrome Patients in the Outpatient ClinicDang, Andrew T. et al. Journal of Allergy and Clinical Immunology , Volume 135 , Issue 2 , AB47

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Clinical Management of Food Protein-Induced Enterocolitis Syndrome.  

Sopo, Stefano Miceli; Iacono, Iride Dello; Greco, Monica; Monti, Giovanna. Clinical management of food protein-induced enterocolitis syndrome. Current Opinion in Allergy & Clinical Immunology. 2014 Jun;14(3):240-245

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Natural History of Food Protein-Induced Enterocolitis Syndrome

Katz, Yitzhak; Goldberg, Michael R. Natural history of food protein-induced enterocolitis syndrome. Current Opinion in Allergy & Clinical Immunology. 2014 Jun;14(3):229-239.

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Definition, Etiology, and Diagnosis of Food Protein-Induced Enterocolitis Syndrome

Feuille, Elizabeth; Nowak-Wegrzyn, Anna. Definition, etiology, and diagnosis of food protein-induced enterocolitis syndrome. Current Opinion in Allergy & Clinical Immunology.2014 Jun;14(3):222-228.

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Food protein-induced enterocolitis syndrome (FPIES): Current management strategies and review of the literature.   

Excerpts from article abstract: “…Certain FPIES features overlap with food protein-induced enteropathy and proctocolitis, whereas others overlap with anaphylaxis. FPIES is not well recognized among pediatricians and emergency department physicians; the affected children are often mismanaged as having acute viral gastrointestinal illness, sepsis, or surgical disease, delaying diagnosis of FPIES for many months. The aim of this review is to provide case-driven presentation of the features of FPIES. Although randomized clinical trials on management options are missing, the relevant current literature and authors’ experience are reviewed in detail.”

Järvinen KM, Nowak-Węgrzyn A. Food protein-induced enterocolitis syndrome (FPIES): Current management strategies and review of the literature. J Allergy Clin Immunol: In Practice 2013;1:317-22. http://dx.doi.org/10.1016/j.jaip.2013.04.004.

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Manifestations, diagnosis, and management of food protein-induced enterocolitis syndrome. 

Leonard SA, Nowak-Wegrzyn A. Manifestations, diagnosis, and management of food protein-induced enterocolitis syndrome. Pediatr Ann. 2013 Jul 1;42(7):135-40. doi: 10.3928/00904481-20130619-11.

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Clinical Diagnosis and Management of Food Protein-Induced Enterocolitis Syndrome.

Excerpts from the abstract summary:“Appreciation of the frequent incidence of multiple food-FPIES has influenced anticipatory guidance. Two case reports have described FPIES to food proteins in maternal breast milk. The threshold dose for FPIES reactivity may decrease with successive episodes. Reports from different populations indicate that children may outgrow FPIES sooner than previously thought.”

Leonard SA, Nowak-Węgrzyn A.  Clinical Diagnosis and Management of Food Protein-Induced Enterocolitis Syndrome.  Curr Opin Pediatr. 2012 Dec;24(6):739-45.

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Food Protein-Induced Enterocolitis Syndrome: An Update on Natural History and Review of Management   

A summary of the history of FPIES and review of the current management of this clinical diagnosis from the leaders in FPIES research at the Jaffe Food Allergy Institute at the Mt. Sinai School of Medicine.  

Leonard, S.; Nowak-Wegrzyn A. Food Protein-Induced Enterocolitis Syndrome: An Update on Natural History and Review of Management. Annals of Allergy, Asthma and Immunology August 2011; 107 (2): 95-101.

Breastfeeding:

Food protein-induced enterocolitis syndrome in two exclusively breastfed infants.

Kaya, A., Toyran, M., Civelek, E., Mısırlıoglu, E. D., Kırsaçlıoglu, C. T. and Kocabaş, C. N. (2016), Food protein-induced enterocolitis syndrome in two exclusively breastfed infants. Pediatr Allergy Immunol. doi:10.1111/pai.12605.

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Chronic Food Protein-Induced Enterocolitis Syndrome Caused by Cow’s Milk Proteins Passed through Breast Milk

Miceli Sopo S, Monaco S, Greco M, Scala G, Chronic Food Protein-Induced Enterocolitis Syndrome Caused by Cow’s Milk Proteins Passed through Breast Milk. Int Arch Allergy Immunol 2014;164:207-209.

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Food Protein-Induced Enterocolitis in an Exclusively Breast-Fed Infant – An Uncommon Entity

From the team that published the 16-yr. experience of FPIES, gathered further unpublished data from Monti et al. of the only published case of FPIES through breast milk, and added a case of acute FPIES in exclusively breast-fed infant, making this 2 published cases of FPIES through breast milk.  

Tan J, Campbell D, Mehr S.   Food Protein-Induced Enterocolitis Syndrome in an Exclusively Breast-Fed Infant-An Uncommon Entity.   J Allergy Clin Immunol.  2012 Mar;129(3):873.

Food protein–induced enterocolitis syndrome by cow’s milk proteins passed through breast milk.  

Written for the The Journal of Allergy and Clinical ImmunologyLetter to the editor,  about a documented case of FPIES from cow’s milk proteins through breast milk.  

Giovanna M., et al. Food Protein-Induced Enterocolitis Syndrome by cow’s milk proteins passed through breast milk. The Journal of Allergy and Clinical Immunology. March 2011; 127 (3): 679-80.

FPIES in Adults:

Food Protein- Induced Enterocolitis Syndrome Can Occur in Adults

A letter to the editor to consider the possibility of FPIES in differential diagnosis on the acute onset of gastrointestinal symptoms experienced in adults.  

Fernandes, B., Boyle R., Gore, C., Simpson A., Custovic, A. Food Protein–Induced Enterocolitis Syndrome Can Occur in Adults.  The Journal of Allergy and Clinical Immunology 2012 Nov; 130 (5): 1199-1200.  

Specific Foods:

Severe Food Protein-Induced Enterocolitis Syndrometo Cow’s Milk in Infants

Yang M, Geng L, Xu Z, et al. Severe Food Protein-Induced Enterocolitis Syndrome to Cow’s Milk in Infants. Nutrients. 2016;8(1):1. doi:10.3390/nu8010001.

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A case of food protein–induced enterocolitis syndrome to mushrooms challenging currently used diagnostic criteria. 

Serafini, Séverine et al. A case of food protein–induced enterocolitis syndrome to mushrooms challenging currently used diagnostic criteria.The Journal of Allergy and Clinical Immunology: In Practice , Volume 3 , Issue 1 , 135 – 137.

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A BEEF CASE: A SHORT REPORT OF FOOD PROTEIN INDUCED ENTEROCOLITIS SYNDROME. 

Sinha A, Korenevs S, Morgan J. A BEEF CASE: A SHORT REPORT OF FOOD PROTEIN INDUCED ENTEROCOLITIS SYNDROME. Pediatric Oncall [serial online] 2014[cited 2014 January-March 1];11. Art #12.  headercolorbar

Food Protein-Induced Enterocolitis caused by fish and or shellfish in Italy.  

Miceli Sopo S, Monaco S. Badina L, Barni S, Longo G. Novembre EM, Viola S, Monti G. Food protein-induced enterocolitis syndrome caused by fish and/or shellfish in Italy. Pediatr Allergy Imunol 2015.

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A Beef Case: A Short Report of Food Protein Induced Enterocolitis Syndrome.   

Sinha A, Korenevs S, Morgan J. A BEEF CASE: A SHORT REPORT OF FOOD PROTEIN INDUCED ENTEROCOLITIS SYNDROME. Pediatric Oncall [serial online] 2014[cited 2014 January-March 1];11. Art #12. Available From : http://www.pediatriconcall.com/Journal/Article/FullText.aspx?artid=677&type=J&tid=&imgid=&reportid=387&tbltype=

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Egg: a frequent trigger of food protein-induced enterocolitis syndrome.  

A Letter to the editor among researchersto highlight that egg is a frequent trigger of food protein–induced enterocolitis syndrome (FPIES) in a recent cohort of patients in Australia  with reply letter  illustrating that although rare reports in previous literature have been made, it is important to recognize any food protein can trigger a reaction. Article refers to: Jean-Christoph Caubet, Anna Nowak-Węgrzyn Food protein–induced enterocolitis to hen’s egg Journal of Allergy and Clinical Immunology, Volume 128, Issue 6, December 2011, Pages 1386-1388.

Hsu P, Mehr S. Egg: a frequent trigger of food protein-induced enterocolitis syndrome. J Allergy Clin Immunol. 2013;131:241–242.    

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Food protein-induced enterocolitis syndrome due to banana: an uncommon entity.

Don M, Longo G. Food protein-induced enterocolitis syndrome due to banana: an uncommon entity. Eur Ann Allergy Clin Immunol. 2013 Apr;45(2):61-2.

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Food protein-induced enterocolitis syndrome triggered by orange juice.  

Federly TJ, Ryan P, Dinakar C. Food protein-induced enterocolitis syndrome triggered by orange juice. Ann Allergy Asthma Immunol. 2012;109:472–473

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Food protein-induced enterocolitis syndrome (FPIES) to corn: a case report.  

Sopo SM, Filoni S, Giorgio V, Monaco S, Onesimo R. Food protein-induced enterocolitis syndrome (FPIES) to corn: a case report. J Investig Allergol Clin Immunol. 2012;22:391–392.

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The Prevalence and Natural Course of Food Protein Induced Enterocolitis Syndrome to Cow’s Milk: A Large-Scale Prospective Population-Based Study 

Katz Y, Goldberg MR, Rajuan N, Cohen A, Leshno M. The prevalence and natural course of food protein induced enterocolitis syndrome to cow’s milk: a large-scale prospective population-based study. J Allergy Clin Immunol 2011;127:647-53,e1-3.

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A case of severe allergic reaction to cooked potato. 

Monti, G., Viola, S., Tarasco, V., Lupica, M., Cosentino, V. and Castagno, E. (2011), A case of severe allergic reaction to cooked potato. Acta Paediatrica, 100: e236–e238. doi: 10.1111/j.1651-2227.2011.02325.x

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Food Protein-Induced Enterocolitis to Hen’s Egg 

From the Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, and the Department of Child and Adolescent, University Hospitals of Geneva and Medical School of the University of Geneva

Caubet J-C, Nowak-Wegrzyn A. Food protein-induced enterocolitis to hen’s egg. J Allergy Clin Immunol 2011.

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Case of Food Protein-Induced Enterocolitis Syndrome Caused by Short-Neck Clam Ingestion.  

Hayashi D, Aoki T, Shibata R, Ichikawa K. Case of Food Protein-Induced Enterocolitis Syndrome Caused by Short-Neck Clam Ingestion. Jpn. J. Allergol., 59 (12): 1628-1633, 2010.

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Rice: A Common and Severe Cause of Food Protein-Induced Enterocolitis Syndrome  

This Australian based study, written in 2009, defines rice FPIES and milk/soy FPIES, as well as the differences and similarities in presentation.  

Mehr, S.; Kakakios, A.; Kemp A. Rice: A Common and Severe Cause of Food Protein-Induced     Enterocolitis Syndrome. Pediatrics November 2009; 124 (Supplement 2): S126 -S127.

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Fruit proteins: another cause of food protein-induced enterocolitis syndrome.  

Bruni F, Peroni DG, Piacentini GL, De Luca G, Boner AL. Fruit proteins: another cause of food protein-induced enterocolitis syndrome. Allergy. 2008;63:1645–1646.

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Indexes of suspicion of typical CM protein-induced enterocolitis. 

Hwang JB, Lee SH, Kang YN, Kim SP, Suh SI, Kam S. Indexes of suspicion of typical CM protein-induced enterocolitis. J Korean Med Sci. 2007;22:993–997.

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Food-Protein-Induced Enterocolitis Syndrome Caused by Fish. 

Study done in Spain connecting pathology related to foods is contributed by its consumption pattern, and varies from country to country with first food introductions.  

Zapatero, R. Alonso, L. Martin, F. Martinez,M. Food-Protein-Induced Enterocolitis Syndrome Caused by Fish. Allergol Immunopathol (Madr). 2005 Nov-Dec;33(6):312-6.

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Food Protein-Induced Enterocolitis Syndrome — Not Only Due to Cow’s Milk and Soy.  

Levy Y, Danon YL. Food protein-induced enterocolitis syndrome — not only due to cow’s milk and soy. Pediatr. Allergy Immunol. 14(4), 325—329 (2003).

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Milk- and Soy Protein-Induced Enterocolitis: Evidence for Lymphocyte Sensitization to Specific Food Proteins.  

Van Sickle GJ, Powell GK, McDonald PJ, Goldblum RM. Milk- and soy protein-induced enterocolitis: evidence for lymphocyte sensitization to specific food proteins.Gastroenterology 88(6), 1915—1921 (1985).

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Milk- and soy-induced enterocolitis of infancy. Clinical features and standardization of challenge 

Describes clinical features of FPIES, first proposals of diagnostic criteria still used today (and referenced in current articles)

Powell GK. Milk- and soy-induced enterocolitis of infancy. Clinical features and standardization of challenge. J. Pediatr. 93(4), 553—560 (1978).

Chronic FPIES:

Immunopathophysiology of food protein–induced enterocolitis syndrome

Berin, M. Cecilia. Immunopathophysiology of food protein–induced enterocolitis syndrome. Journal of Allergy and Clinical Immunology , Volume 135 , Issue 5 , 1108 – 1113. 

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Clinical Manifestations of Food Protein-Induced Enterocolitis Syndrome 

Mane SKBahna SL. Clinical Manifestations of Food Protein-Induced Enterocolitis Syndrome. Current Opinion in Allergy & Clinical Immunology. 2014 Jun;14(3):217-221.

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Chronic Food Protein-Induced Enterocolitis Syndrome Caused by Cow’s Milk Proteins Passed through Breast Milk

Miceli Sopo S, Monaco S, Greco M, Scala G, Chronic Food Protein-Induced Enterocolitis Syndrome Caused by Cow’s Milk Proteins Passed through Breast Milk. Int Arch Allergy Immunol 2014;164:207-209.

Gastroenterology:

Clinical Characteristics of Non-IgE-Mediated Gastrointestinal Food Allergy: Analysis of Nation-Wide Web-Based Online Patient Registry. 

Nomura, Ichiro et al. Clinical Characteristics of Non-IgE-Mediated Gastrointestinal Food Allergy: Analysis of Nation-Wide Web-Based Online Patient Registry. Journal of Allergy and Clinical Immunology , Volume 137 , Issue 2 , AB241

Endoscopic findings in the acute phase of food protein-induced enterocolitis syndromae Letter to the Editor. 

Takashi Ishige, Hisako Yagi, Maiko Tatsuki, Reiko Hatori, Yutaka Nishida, Takumi Takizawa, Hirokazu Arakawa. Endoscopic findings in the acute phase of food protein-induced enterocolitis syndromae Letter to the Editor.Pediatric Allergy and Immunology Volume 26, Issue 1, pages 90–91, February 2015.

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Feeding Difficulties in Children with Food Protein Induced Gastrointestinal Allergies

Meyer R, Rommel N, Van Oudenhove L, Fleming C, Dziubak R, Shah N. Feeding difficulties in children with food protein induced gastrointestinal allergies. J Gastroenterol Hepatol. 2014 Apr 10.

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Infants with Food Protein-Induced Enterocolitis Syndrome (FPIES) Can Be Classified Into Two Distinct Subgroups Based On the Presence or Absence of Bloody Stool and Their Antigen-Specific Cytokine Production Profiles.   

Hideaki Morita, Ichiro Nomura, Tetsuo Shoda, Hirotoshi Unno, Akio Matsuda, Hirohisa Saito, Kenji Matsumoto, et al.  Infants with Food Protein-Induced Enterocolitis Syndrome (FPIES) Can Be Classified Into Two Distinct Subgroups Based On the Presence or Absence of Bloody Stool and Their Antigen-Specific Cytokine Production Profiles.  Journal of Allergy and Clinical Immunology Vol. 131, Issue 2, Supplement, Page AB182.

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Four Distinct Subtypes of Non-IgE-Mediated Gastrointestinal Food Allergies in Neonates and Infants, Distinguished by Their Initial Symptoms  

Nomura, I. et al. Four distinct subtypes of non-IgE-mediated gastrointestinal food allergies in neonates and infants, distinguished by their initial symptoms. The Journal of Allergy and Clinical Immunology, March 2011; 127(3):685-688.

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Gastrointestinal Food Allergy in Infants

Discussion of some of the current diagnostic and research for GI allergies. 

Hideaki Morita1, Ichiro Nomura, Akio Matsuda1, Hirohisa Saito and Kenji Matsumoto. Gastrointestinal Food Allergy in Infants. Allergology International 2013; 62: 297-307. 

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Manifestations of Food Protein Induced Gastrointestinal Allergies Presenting to a Single Tertiary Paediatric Gastroenterology Unit

A large retrospective study on children with food induced gastrointestinal allergies.  

Meyer et al: Manifestations of food protein induced gastrointestinal allergies presenting to a single tertiary paediatric gastroenterology unit.  World Allergy Organization Journal 2013 6:13.

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Gastrointestinal Manifestations of Food Allergies.  

Discusses EoE and also mentions FPIES.

Wolfe JL, Aceves SS. Gastrointestinal Manifestations of Food Allergies Pediatr Clin North Am. 2011 Apr;58(2):389-405, x. Clinical Presentation of Food Allergy.

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Clinical Aspects of Pediatric Food Allergy and Failed Oral Immune Tolerance.  

Allen KJ, Martin PE. Clinical Aspects of Pediatric Food Allergy and Failed Oral Immune Tolerance. J Clin Gastroenterol. 2010 Jul;44(6):391-401.1.

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Summary and Recommendations: Classification of Gastrointestinal Manifestations Due to Immunologic Reactions to Foods in Infants and Young Children.  

This article written from Mount Sinai School of Medicine provides discussions on the differential diagnosis of immune system reactions of the gastrointestinal tract, with a classification of food allergies from immediate (IgE) to Non-IgE and Mixed IgE/Non-IgE.  

Sampson HA, Anderson JA. Summary and recommendations: classification of gastrointestinal manifestations due to immunologic reactions to foods in infants and young children. J. Pediatr. Gastroenterol. Nutr. 30(Suppl.), S87—S94 (2000).

Mechanisms:

Cytokine profile after oral food challenge in infants with food protein-induced enterocolitis syndrome.

Kimura, Mitsuaki; Ito, Yasunori; Shimomura, Masaki;Morishita, Hideaki; Meguro, Takaaki; Adachi, Yuichi; Seto, Shiro. Cytokine profile after oral food challenge in infants with food protein-induced enterocolitis syndrome. Allergology International. 

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Serum C-reactive protein in food protein-induced enterocolitis syndrome versus food protein-induced proctocolitis in Japan.  

Kimura, M., Shimomura, M., Morishita, H., Meguro, T. and Seto, S. (2016), Serum C-reactive protein in food protein-induced enterocolitis syndrome versus food protein-induced proctocolitis in Japan. Pediatrics International, 58: 836–841. doi:10.1111/ped.13036

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Increased CD69 Expression on Peripheral Eosinophils from Patients with Food Protein-Induced Enterocolitis Syndrome.

Wada T, Matsuda Y, Toma T, Koizumi E, Okamoto H, Yachie A, Increased CD69 Expression on Peripheral Eosinophils from Patients with Food Protein-Induced Enterocolitis Syndrome. Int Arch Allergy Immunol 2016;170:201-205

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Clinical and immunological characteristics of a pediatric population with food protein-induced enterocolitis syndrome (FPIES) to fish.

González-Delgado P, Caparrós E, Moreno MV, Clemente F, Flores E, Velásquez L, Rubio G, Fernández J. Clinical and immunological characteristics of a pediatric population with food protein-induced enterocolitis syndrome (FPIES) to fish. Pediatr Allergy Immunol 2016: 27: 269–275.

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Transient Massive Trimethylaminuria Associated with Food Protein–Induced Enterocolitis Syndrome. 

Natalie B. Miller; Avraham Beigelman; Elizabeth Utterson; Marwan Shinawi . Transient Massive Trimethylaminuria Associated with Food Protein–Induced Enterocolitis Syndrome. JIMD Reports Volume 12, 2014, pp 11-15.

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Humoral and cellular responses to casein in patients with food protein–induced enterocolitis to cow’s milk

Caubet, Jean Christoph et al. H umoral and cellular responses to casein in patients with food protein–induced enterocolitis to cow’s milk. Journal of Allergy and Clinical Immunology , Volume o , Issue 0.

Immunopathophysiology of food protein–induced enterocolitis syndrome

Berin, M. Cecilia. Immunopathophysiology of food protein–induced enterocolitis syndrome. Journal of Allergy and Clinical Immunology , Volume 135 , Issue 5 , 1108 – 1113

Food Protein-Induced Enterocolitis caused by fish and or shellfish in Italy.  

Miceli Sopo S, Monaco S. Badina L, Barni S, Longo G. Novembre EM, Viola S, Monti G. Food protein-induced enterocolitis syndrome caused by fish and/or shellfish in Italy. Pediatr Allergy Imunol 2015.

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The role of casein-specific IgA and TGF-β in children with food protein-induced enterocolitis syndrome to milk.  

Konstantinou, George N., Bencharitiwong, Ramon, Grishin, Alexander, Caubet, Jean-Christoph., Bardina, Luda.,  Sicherer, Scott H.,Sampson, Hugh A., Nowak-Węgrzyn, Anna. Pediatr Allergy Immunol. 2014 Nov;25(7):651-6. 

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Epidemiology of Food Protein-Induced Enterocolitis Syndrome.

Mehr, Sam; Frith, Katie; Campbell, Dianne E. Epidemiology of food protein-induced enterocolitis syndrome. Current Opinion in Allergy & Clinical Immunology. 2014 Jun;14(3):209-216.

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T Cell Responses to Food Protein in Acute Food Protein-Induced Enterocolitis (FPIES).  

Jean-Christoph Caubet, Ramon Bencharitiwong, Madhan Masilamani, Hugh A. Sampson, Cecilia Berin, Anna H. Nowak-Wegrzyn . T Cell Responses to Food Protein in Acute Food Protein-Induced Enterocolitis (FPIES).  The Journal of Allergy and Clinical Immunology – February 2013 (Vol. 131, Issue 2, Supplement, Page AB183, DOI: 10.1016/j.jaci.2012.12.1318)

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Current Understanding of the Immune Mechanisms of FPIES. Expert Review  

This is the most current and comprehensive article on FPIES immune mechanisms. Doctors at the Jaffe Food Allergy Institute at the Mt. Sinai School of Medicine recognize that FPIES is an under recognized and frequently misdiagnosed allergy, and outline the current understandings and future potential of FPIES research.  

Caubet, J.;Nowak-Wegrzyn, A. Current Understanding of the Immune Mechanisms of FPIES. Expert Review.Clinical Immunology. 2011; 7(3), 317-327.

Lab Findings:

Eosinophilia in infants with food protein-induced enterocolitis syndrome in Japan. 

 Kimura, Mitsuaki et al. Japan Eosinophilia in infants with food protein-induced enterocolitis syndrome in Japan.  Allergology International , Volume 0 , Issue 0.

Elevation of fecal eosinophil-derived neurotoxin in infants with food protein-induced enterocolitis syndrome

Wada T, Toma T, Muraoka M, Matsuda Y, Yachie A  Elevation of fecal eosinophil-derived neurotoxin in infants with food protein-induced enterocolitis syndrome. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 25:6 2014 Oct pg 617-9 

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Transient Massive Trimethylaminuria Associated with Food Protein–Induced Enterocolitis Syndrome

Miller NB, Beigelman A, Utterson E, Shinawi M. Transient Massive Trimethylaminuria Associated with Food Protein–Induced Enterocolitis Syndrome. JIMD Reports Volume 12, 2014, pp 11-15

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Antigen-specific T-cell responses in patients with non–IgE-mediated gastrointestinal food allergy are predominantly skewed to TH2.   

Hideaki Morita, Ichiro Nomura, Kanami Orihara, Koichi Yoshida, Akira Akasawa, Hiroshi Tachimoto, Yoshikazu Ohtsuka, Yoshiyuki Namai, Masaki Futamura, Tetsuo Shoda, Akio Matsuda, Norio Kamemura, Hiroshi Kido, Takao Takahashi, Yukihiro Ohya, Hirohisa Saito, Kenji Matsumoto et al.    Antigen-specific T-cell responses in patients with non–IgE-mediated gastrointestinal food allergy are predominantly skewed to TH2.  Journal of Allergy and Clinical Immunology Vol. 131, Issue 2, Pages 590-592.e6.  Feb. 2013.

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Systemic Cytokine Responses in Acute Food Protein-Induced Enterocolitis (FPIES)

Anna H. Nowak-Wegrzyn, Thomas Kraus, Ramon Bencharitiwong, Thomas Moran, Hugh A. Sampson.  Systemic Cytokine Responses in Acute Food Protein-Induced Enterocolitis (FPIES). The Journal of Allergy and Clinical Immunology – February 2013 (Vol. 131, Issue 2, Supplement, Page AB183, DOI: 10.1016/j.jaci.2012.12.1317)

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Poor Utility of Atopy Patch Test in Predicting Tolerance Development in Food Protein-Induced Enterocolitis Syndrome

Järvinen KM, Caubet JC, Sickles L, Ford LS, Sampson HA, Nowak-WęgrzynA.  Poor Utility of Atopy Patch Test in Predicting Tolerance Development in Food Protein-Induced Enterocolitis Syndrome.  Ann Allergy Asthma Immunol. 2012 Sep;109(3):221-2.

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Elevation of Serum IL-17 Levels was Demonstrated after Oral Food Challenge in Infants with Food Protein-Induced Enterocolitis Syndrome.   

T. Shoda, K. Hashimoto, H. Morita, I. Nomura, A. Isozaki, Y. Ohya, T. Ichiyama, H. Saito, K. Matsumoto, Y. Kawano, et al.  Elevation of Serum IL-17 Levels was Demonstrated after Oral Food Challenge in Infants with Food Protein-Induced Enterocolitis Syndrome.  Journal of Allergy and Clinical Immunology Vol. 127, Issue 2, Supplement, Page AB243.  Feb. 2011

Nutrition Management:

Half Cow’s Milk-Induced Food Protein Induced Enterocolitis Syndrome (FPIES) Require Amino Acid Feeding.

Blanc, Sibylle et al.Half Cow’s Milk-Induced Food Protein Induced Enterocolitis Syndrome (FPIES) Require Amino Acid Feeding. Journal of Allergy and Clinical Immunology , Volume 137 , Issue 2 , AB229

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Doctor, when should I feed solid foods to my infant?

Fiocchi A1, Dahdah L, Bahna SL, Mazzina O, Assa’ad A., Doctor, when should I feed solid foods to my infant?  Curr Opin Allergy Clin Immunol. 2016 Aug;16(4):404-11

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Optimizing an Aversion Feeding Therapy Protocol for a Child with Food Protein-Induced Enterocolitis Syndrome (FPIES)

Mattingly R (2015) Optimizing an Aversion Feeding Therapy Protocol for a Child with Food Protein-Induced Enterocolitis Syndrome (FPIES). J Pulm Respir Med 5: 287

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Nutritional management of food protein-induced enterocolitis syndrome. 

Carina Venter; Marion Groetch. Current Opinion in Allergy and Clinical Immunology. Nutritional management of food protein-induced enterocolitis syndrome. Current Opinion in Allergy and Clinical Immunology. June 2014, p 255-262.

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Innate Immune Responses Differ In Patients With Food Protein Induced Enterocolitis Syndrome (FPIES) Who Respond Well To The Restrictive Diet And Those Who Do Not.

V. Rahimian, L. Geng, P. Kattouf, H. Jyonouchi.  Innate Immune Responses Differ In Patients With Food Protein Induced Enterocolitis Syndrome (FPIES) Who Respond Well To The Restrictive Diet And Those Who Do Not.  Journal of Allergy and Clinical Immunology Vol. 129, Issue 2, Supplement, Page AB96

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Food protein-induced enterocolitis to casein hydrolysate formulas

Kelso JM1, Sampson HA. Food protein-induced enterocolitis to casein hydrolysate formulas. J Allergy Clin Immunol. 1993 Dec;92(6):909-10

Case Studies:

Food Protein-Induced Gastrointestinal Syndromes in Identical and Fraternal Twins. 

Shoda, Tetsuo et al. Food Protein-Induced Gastrointestinal Syndromes in Identical and Fraternal Twins. Allergology International , Volume 60 , Issue 1 , 103 – 108.

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Oral food challenge with a mixture of ‘at risk’ foods in children with FPIES

Miceli Sopo, S., Bersani, G., Cerchiara, G. and Monaco, S. (2016), Oral food challenge with a mixture of ‘at risk’ foods in children with FPIES. Pediatr Allergy Immunol, 27: 874–876. doi:10.1111/pai.12623

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FPIES: Reviewing the Management of Food Protein-Induced Enterocolitis SyndromeNeha Khanna and Kirtika Patel, “FPIES: Reviewing the Management of Food Protein-Induced Enterocolitis Syndrome,” Case Reports in Pediatrics, vol. 2016, Article ID 1621827, 5 pages, 2016. doi:10.1155/2016/1621827

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Food Induced Gastroenterocolitis Syndrome(FPIES): A Case Series of 51 Children.  Food Induced Gastroenterocolitis Syndrome(FPIES): A Case Series of 51 Children. Villafana, Liseth et al. Journal of Allergy and Clinical Immunology , Volume 135 , Issue 2 , AB47

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Optimizing an Aversion Feeding Therapy Protocol for a Child with Food Protein-Induced Enterocolitis Syndrome (FPIES)

Mattingly R (2015) Optimizing an Aversion Feeding Therapy Protocol for a Child with Food Protein-Induced Enterocolitis Syndrome (FPIES). J Pulm Respir Med 5: 287.

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A Beef Case: A Short Report of Food Protein Induced Enterocolitis Syndrome.   

Sinha A, Korenevs S, Morgan J. A BEEF CASE: A SHORT REPORT OF FOOD PROTEIN INDUCED ENTEROCOLITIS SYNDROME. Pediatric Oncall [serial online] 2014[cited 2014 January-March 1];11. Art #12.

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Use of Ondansetron for Food Protein–Induced Enterocolitis Syndrome. 

From John Hopkins University School of Medicine, a letter to the editor published in the Journal of Allergy and Clinical Immunology in July, 2013 edition. 

Holbrook T, Keet CA, Frischmeyer-Guerrerio PA, Wood RA. Use of ondansetron for food protein-induced enterocolitis syndrome. J Allergy Clin Immunol. 2013 Jul 25. pii: S0091-6749(13)00989-5.

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Food protein-induced enterocolitis syndrome to trivial oral mucosal contact.  

Mane SK, Hollister ME, Bahna SL. Food protein-induced enterocolitis syndrome to trivial oral mucosal contact. Eur J Pediatr. 2013 May 29.

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Egg: a frequent trigger of food protein-induced enterocolitis syndrome.  

A Letter to the editor among researchersto highlight that egg is a frequent trigger of food protein–induced enterocolitis syndrome (FPIES) in a recent cohort of patients in Australia  with reply letter  illustrating that although rare reports in previous literature have been made, it is important to recognize any food protein can trigger a reaction.

Article refers to: Jean-Christoph Caubet, Anna Nowak-Węgrzyn Food protein–induced enterocolitis to hen’s egg Journal of Allergy and Clinical Immunology, Volume 128, Issue 6, December 2011, Pages 1386-1388.

Hsu P, Mehr S. Egg: a frequent trigger of food protein-induced enterocolitis syndrome. J Allergy Clin Immunol. 2013;131:241–242.    

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Food protein-induced enterocolitis syndrome due to banana: an uncommon entity.

Don M, Longo G. Food protein-induced enterocolitis syndrome due to banana: an uncommon entity. Eur Ann Allergy Clin Immunol. 2013 Apr;45(2):61-2.

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Food protein-induced enterocolitis syndrome triggered by orange juice.  

Federly TJ, Ryan P, Dinakar C. Food protein-induced enterocolitis syndrome triggered by orange juice. Ann Allergy Asthma Immunol. 2012;109:472–473

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Four Infants Presenting with Severe Vomiting in Solid Food Protein-Induced Enterocolitis Syndrome: A Case Series.  

Bansal AS, Bhaskaran S, Bansal RA. Four Infants Presenting with Severe Vomiting in Solid Food Protein-Induced Enterocolitis Syndrome: A Case Series.   J Med Case Rep. 2012 Jun 26;6(1):160.

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Food protein-induced enterocolitis syndrome (FPIES) and well cooked foods: A working hypothesis.  

Miceli Sopo S, et al. Food protein-induced enterocolitis syndrome (FPIES) and well cooked foods: A working hypothesis. Allergol Immunopathol (Madr). 2012. 

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Food Protein-induced Enterocolitis Syndrome (FPIES): Our Experience. 

A paper from Spain, in Feb. 2012 highlighting  the average age of resolution is higher than that reported by other authors.  

M. Ruiz Garcia.  Food Protein-induced Enterocolitis Syndrome (FPIES): Our Experience.  Journal of Allergy and Clinical Immunology Vol. 129, Issue 2, Supplement, Page AB34.

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Food protein-induced enterocolitis syndrome (FPIES) to corn: a case report.  

Sopo SM, Filoni S, Giorgio V, Monaco S, Onesimo R. Food protein-induced enterocolitis syndrome (FPIES) to corn: a case report. J Investig Allergol Clin Immunol. 2012;22:391–392.

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Food Protein-Induced Enterocolitis Syndrome as a  Cause for Infant Hypotension. 

From the abstract: “FPIES should be considered in infants presenting with gastrointestinal complaints and hypotension. A dietary history, including if a new food has been introduced in the last few hours, may help facilitate earlier recognition of the syndrome.”   

Coates RW, Weaver KR, Lloyd R, Ceccacci N, Greenberg MR. Food Protein-Induced Enterocolitis Syndrome as a Cause for Infant Hypotension.  West J Emerg Med. 2011 Nov;12(4):512-4.

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Hematochezia before the First Feeding in a Newborn with Food Protein-Induced Enterocolitis Syndrome. 

Masanori Mizuno, Ph.D., M.D.,Hiroshi Masaki, M.D., Ryoko Yoshinare, M.D.,Yujun Ito, M.D., Hideyuki Morita, M.D., and Hiroyuki Yoshio, Ph.D., M.D. Hematochezia before the First Feeding in a Newborn with Food Protein-Induced Enterocolitis Syndrome. AJP Rep. Sep 2011; 1(1): 53–58.

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A case of severe allergic reaction to cooked potato. 

Monti, G., Viola, S., Tarasco, V., Lupica, M., Cosentino, V. and Castagno, E. (2011), A case of severe allergic reaction to cooked potato. Acta Paediatrica, 100: e236–e238. doi: 10.1111/j.1651-2227.2011.02325.x

Case Report: . Can food protein induced enterocolitis syndrome shift to immediate gastrointestinal hypersensitivity? A report of two cases.

R. Onesimo, I. Dello Iacono, V.Giorgio, M.G. Limongelli, S.Miceli Sopo. Can Food Protein Induced Enterocolitis Syndrome Shift to Immediate Gastrointestinal Hypersensitivy? A Report of Two Cases.  Eur Ann Allergy Clin Immunol VOL 43, N 2, 61-63, 2011.

Eosinophilic Inflammation Is Prominent In Food Protein-induced Enterocolits Syndrome, Multi-center Case-series Study.   

I. Nomura, T. Fukuie, Y. Ohya, A. Terada, S. Hosokawa, N. Ohtsuka, H. Hoshina, M. Watanabe, A. Isozaki, N. Ito, K. Ito Eosinophilic Inflammation Is Prominent In Food Protein-induced Enterocolits Syndrome, Multi-center Case-series Study. The Journal of Allergy and Clinical Immunology – February 2009 (Vol. 123, Issue 2, Supplement, Page S246, DOI: 10.1016/j.jaci.2008.12.948).  2009

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Food Protein-Induced Enterocolitis Syndrome: Case Presentations and Management Lessons   

Written by doctors at the Jaffe Food Allergy Institute at Mt. Sinai School of Medicine.  

Sicherer, S. Food Protein-Induced Enterocolitis Syndrome: Case Presentations and Management Lessons.   The Journal of Allergy and Clinical Immunology. January 2005; 115 (1): 149-156

We have compiled a list of some of the best and most recent medical articles for you or your doctors to review.

We will continue to add to this index as more information is published and available. 

**Of note, some online journal publications may be links to abstracts only with full access available for that journal subscribing members.

A Printable List of Articles to Bring to Your Child’s Practitioner:

Additional Related Publications:

The Differential Diagnosis of Food Protein-Induced Enteropathy by Intestinal Mucosal Pathology

Kudo, Oka, Arai, Shimizu. The differential diagnosis of food protein-induced enteropathy by intestinal mucosal pathology. Nihon Shoni Arerugi Gakkaishi The Japanese Journal of Pediatric Allergy and Clinical Immunology 31(1):7-12 · January 2017. 

ASD and Food Allergy.  Harumi Jyonouchi. ASD and Food Allergy.  Comprehensive Guide to Autism 2014, pp 1995-2013

Allergen Patch Test in Children With Food Allergy-Related Gastrointestinal Symptoms   

Visitsunthorn, N.; Boonyaviwat, O.; Pacharn, P.; Piboonpocanun, O.; Vichyanond, P.Allergen Patch Test in Children With Food Allergy-related Gastrointestinal Symptoms.The Journal of Allergy and Clinical Immunology. February 2011; 127(2): AB181.

The Optimal Diagnostic Workup for Children with Suspected Food Allergy.   

Berni Canani R, Di Costanzo M, Troncone R. The Optimal Diagnostic Workup for Children with Suspected Food Allergy.  Nutrition. 2011 Oct;27(10):983-7.

Clinical Presentation of Food Allergy 

Food allergies as immune-mediated responses are discussed; and as occuring with varying clinical presentations.  

Mansoor DK, Sharma HP. Clinical Presentation of Food Allergy. Pediatr Clin North Am. 2011 Apr;58(2):315-26, ix.

Guidelines for the Diagnosis and Management of Food Allergy in the United States: Report of the NIAID-Sponsored Expert Panel  

A full review of the latest guidelines for food allergy.  See section 4.3.2 for FPIES information.  NIAID-Sponsored Expert panel.  

Guidelines for the Diagnosis and Management of Food Allergy in the United States: Report of the NIAID-Sponsored Expert Panel. The Journal of Allergy and Clinical Immunology. December 2010; 126 (6): S1-S58.

Food Allergy: Review, Classification and Diagnosis  

Written in 2009, this article describes IgE allergy, oral tolerance and Non-IgE allergy in the context of rising food allergy diagnosis and treatments. Includes an excellent graph to illustrate IgE, Non-IgE and intolerance’s

Cianferoni, A.; Spergel, J.M. Food Allergy: Review, Classification and Diagnosis. Allergology International. 2009; 58:457-466.

Educational clinical case series for pediatric allergy and immunology: allergic proctocolitis, food protein-induced enterocolitis syndrome and allergic eosinophilic gastroenteritis with protein-losing gastroenteropathy as manifestations of non-IgE-mediated cow’s milk allergy.  

Maloney J, Nowak-Wegrzyn A. Educational clinical case series for pediatric allergy and immunology: allergic proctocolitis, foodprotein-induced enterocolitis syndrome and allergic eosinophilic gastroenteritis with protein-losing gastroenteropathy as manifestations of non-IgE-mediated cow’s milk allergy. Pediatr Allergy Immunol. 2007 Jun;18(4):360-7.

Rice-induced enterocolitis in an infant: TH1/TH2 cellular hypersensitivity and absent IgE reactivity.  

Gray HC, Foy TM, Becker BA, Knutsen AP. Rice-induced enterocolitis in an infant: TH1/TH2 cellular hypersensitivity and absent IgE reactivity. Ann. Allergy Asthma Immunol. 93(6), 601—605 (2004).

The Mother of All Food Allergy  

This article was written as a commentary to an article published in the same issue of The Journal of Pediatrics: “A consistent pattern of minor immunodeficiency and subtle enteropathy in children with multiple food allergy,” by a leading gastroenterologist in  Eosinophilic disorders. It offers a perspective from the medical community.  

Putnam, P. The Mother of All Food Allergy.The Journal of Pediatrics. July 2003; 143 (1): 7-9.

A Consistent Pattern of Minor Immunodeficiency and Subtle Enteropathy in Children with Multiple Food Allergy 

Latcham et al. A Consistent Pattern of Minor Immunodeficiency and Subtle Enteropathy in Children with Multiple Food Allergy The Journal of Pediatrics 2003; 143:39-47.

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Page published: June 21, 2012 Last update: Feb. 24, 2017. Copyright © 2012,The FPIES Foundation